Thrombin-induced secretion of serotonin from platelets can occur in seconds.
نویسندگان
چکیده
The platelet release reaction was studied by a new quenched-flow approach. Platelets labeled with 14C-serotonin were reacted for short times (up to 5 sec) with thrombin and then quenched with glutaraldehyde or paraformaldehyde. Serotonin secretion began within 1 sec and was nearly complete by 4 sec. Aggregation recorded by a resistive-particle counter was similarly fast. Therefore, the quenched-flow system reveals that serotonin secretion can occur more rapidly than estimated in earlier studies.
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عنوان ژورنال:
- Blood
دوره 60 5 شماره
صفحات -
تاریخ انتشار 1982